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Thus it requires roughly 50–100 ordinary cups of coffee to reach a lethal dose.
However pure powdered caffeine, which is available as a dietary supplement, can be lethal in tablespoon-sized amounts.
The daily dose of 2.5 mg/kg body weight would not cause adverse health effects in the majority of adolescent caffeine consumers.
This is a conservative suggestion since older and heavier weight adolescents may be able to consume adult doses of caffeine without suffering adverse effects.
For children age 12 and under, Health Canada recommends a maximum daily caffeine intake of no more than 2.5 milligrams per kilogram of body weight.
Based on average body weights of children, this translates to the following age-based intake limits: Health Canada has not developed advice for adolescents because of insufficient data.
However, they suggest that daily caffeine intake for this age group be no more than 2.5 mg/kg body weight.
This is because the maximum adult caffeine dose may not be appropriate for light weight adolescents or for younger adolescents who are still growing.
Caffeine citrate is on the WHO Model List of Essential Medicines.
Some people experience insomnia or sleep disruption if they consume caffeine, especially during the evening hours, but others show little disturbance.
Caffeine does not appear to be a reinforcing stimulus, and some degree of aversion may actually occur, with people preferring placebo over caffeine in a study on drug abuse liability published in an NIDA research monograph.
Withdrawal can cause mild to clinically significant distress or impairment in daily functioning.
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